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Yes bupropion is not a steroid, and i am not aware of any contraindications to your drug combinations, but would just express some concern that steroids increase the chances of stomach ulcers and bleeding, and nsaids may worsen this.

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bupropion and its metabolites erythohydrobupropion, threohydrobupropion, hydroxybupropion are cyp2d6 inhibitors.

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clinicians should be aware that digoxin levels may rise on discontinuation of bupropion and the patient should be monitored for possible digoxin toxicity.

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it should be noted that bupropion hydrochloride extended-release tablets xl are not approved for use in treating bipolar depression.

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