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, olanzapine, risperidone are considered dangerous when used in patients with dementia, and the fda has issued a black box warning that elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk for death mainly due to cardiovascular or infectious causes compared with placebo 45 .

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table 17 treatment-emergent extrapyramidal symptoms assessed by adverse reactions incidence in a fixed dosage range, placebo-controlled clinical trial of oral olanzapine in schizophrenia – acute phase.

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because olanzapine may lower blood pressure, it may reduce blood pressure to dangerously low levels if taken with drugs that are used to treat high blood pressure.

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elevated levels of insulin, leptin, and blood lipids in olanzapine-treated patients with schizophrenia or related psychoses.

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1 like in treatment with other antipsychotics, treatment with olanzapine requires a regular monitoring of blood sugar and lipids.

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even though an incremental cost-effectiveness or cost-utility analysis was not performed to assess whether the benefits of olanzapine are worth the additional costs, the authors pointed out that it would seem unlikely that olanzapine would have proven to be cost-effective.


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