However the risk of tardive dyskinesia increases with long term exposure, and therefore if signs or symptoms of tardive dyskinesia appear in a patient on olanzapine, a dose reduction or discontinuation should be considered.
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adults – the efficacy of symbyax for the acute treatment of depressive episodes associated with bipolar i disorder was established in 2 identically designed, 8-week, randomized, double-blind, controlled studies of patients who met diagnostic and statistical manual 4th edition dsm-iv criteria for bipolar i disorder, depressed utilizing flexible dosing of symbyax 6 25, 6 50, or 12 50 mg day , olanzapine 5 to 20 mg day , and placebo.
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in general, an elevated risk of acute dystonia may be observed in males and younger age groups receiving antipsychotics; however, events of dystonia have been reported infrequently 1 with the olanzapine and fluoxetine combination.
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agency for healthcare research and quality concludes that olanzapine is not different from haloperidol in the treatment of positive symptoms and general psychopathology, or in overall assessment, but that it is superior for the treatment of negative and depressive symptoms.
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seven pregnancies were observed during clinical trials with olanzapine, including 2 resulting in normal births, 1 resulting in neonatal death due to a cardiovascular defect, 3 therapeutic abortions, and 1 spontaneous abortion.
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