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In vivo, isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate.

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vinblastine minor isoniazid, inh is an inhibitor of cytochrome p450 isoenzyme 3a4.

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dom-isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall.

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in a meta-analysis of eight randomized controlled studies involving a total of 10,320 patients aged 15 years or younger, ayieko et al found that isoniazid prophylaxis reduced the risk of developing tb, with a pooled risk ratio rr of 0.

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the manufacturer suggests that potent cyp3a4 inhibitors, such as isoniazid, may alter mmae exposure as mmae is a cyp3a4 substrate.

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